Hiv Pre-Exposure Prophylaxis (PrEp)
Posted by | Posted in Hiv Infection Articles | Posted on 16-02-2012
The most basic request to ask is “What is Hiv pre-exposure prophylaxis (PrEp)?”
Pre-exposure prophylaxis is any treatment you take to preclude catching a disease before you get exposure to it. So, you take this treatment to preclude catching an Hiv infection, before you get exposure to the virus. This treatment protocol uses antiretroviral drugs used in treating Hiv infections. The drugs that researchers are testing are tenofovir and emtricitabine in a combined tablet. Studies, done in animal models, demonstrated that this compound was very sufficient for preventing infection. A huuman trial performed last year also demonstrated that this compound was able to cut down on potential infections. The median discount was 42 percent (range: 15 to 65 percent agreeing to cases).
What is required for Hiv pre-exposure prophylaxis (PrEp) to work effectively?
One dissimilarity in the middle of the animal and human studies is the fact that human beings are not in cages and closely monitored. The human trials involve giving the medications to high-risk groups and having them record for testing every few weeks. Test subjects who stuck with the drug protocol closely had more security than those that did not result the protocol closely. So, in order for this to work, those taking the drugs must closely result protocols in order to get the most result from it. They were also advised to systematically use condoms, and these arresting measures were assessed and repeated at each protocol visit.
Which groups would advantage from Hiv pre-exposure prophylaxis (PrEp)?
The safest method for preventing transmission of the Hiv virus involves not having unprotected sex or not sharing used drug needles. The pre-exposure prophylaxis can be seen as an additional portion of prevention. Some have suggested it would work for couples who want to conceive children when one partner is Hiv sure and the other one is not. Someone else use would be among women who have no choice on insisting their partners use condoms. Because the PrEp is not 100% effective, this should be a secondary arresting measure.
What are base concerns about the use of Hiv pre-exposure prophylaxis (PrEp)?
In the Us, Aids organizations have expressed concerns that using PrEp would potentially give a false sense of safety. This might lead to lower usage of condoms among high-risk populations. Someone else concern raised is the fact that using the drug before an infection would build up drug resistance in case of infection in the future. There are ethical concerns about how the drug testing goes on among high-risk populations. These concerns consist of the use of a placebo with a deadly disease and the lack of counseling trial patients receive in some locations. The PrEp may be a step in the right direction, but it is not the excellent answer.
Finally, Someone else ethical concern is production ready antiretroviral drugs for arresting to uninfected peopulations who can afford them, although millions of infected patients around the world cannot afford this therapy!
